This is the index for the DogHealth research hub. The infectious disease work covers canine parvovirus (CPV) and canine distemper (CDV / moquillo): each has a practitioner-facing clinical update, a full research synthesis in both English and Spanish, and CPV adds an interactive knowledge graph. There's also a set of plain-language guides written for dog owners rather than clinicians, starting with cruciate ligament injury, the one most people search for as a torn ACL. Use the links below to jump straight to whichever page you need.
Canine Parvovirus Research Wiki (updated regularly)
A continuously updated synthesis of our canine parvovirus research: transmission, strain prevalence, vaccine failure, treatments, hyperimmune plasma, and prognosis, with every claim tied to its source.
Open the research wiki →Complete Page Index
English
Canine Parvovirus: Clinical Update for Vets
Practitioner-facing clinical update on canine parvovirus (English).
Open page (English) →Canine Parvovirus: Full Research Synthesis
Full global research synthesis on CPV treatments, vaccines, and gaps (English).
Open synthesis (English) →Canine Parvovirus: Interactive Knowledge Graph
Interactive research knowledge graph: viruses, treatments, researchers, and papers.
Open knowledge graph →Canine Distemper: Clinical Update for Vets
Practitioner-facing clinical update on canine distemper (English).
Open page (English) →Canine Distemper: Treatment-Frontier Synthesis
Treatment-frontier synthesis on canine distemper: acute antivirals and post-distemper care (English).
Open synthesis (English) →Español
Parvovirus Canino: Actualización Clínica
Actualización clínica del parvovirus canino para veterinarios (Español).
Abrir página (Español) →Parvovirus Canino: Síntesis de Investigación
La síntesis completa de investigación sobre el parvovirus canino (Español).
Abrir síntesis (Español) →Moquillo Canino: Actualización Clínica
Actualización clínica del moquillo canino para veterinarios (Español).
Abrir página (Español) →Moquillo Canino: Síntesis de Tratamiento
La síntesis sobre el tratamiento del moquillo canino (Español).
Abrir síntesis (Español) →Guides for Dog Owners
Plain-language guides for the person whose dog is limping, not for the clinic. Cruciate ligament injury (the "torn ACL" almost everyone searches for) is the first cluster.
Torn ACL in Dogs: What a CCL Tear Actually Is
Why it's usually degenerative rather than a sports injury, how it presents, how vets diagnose it, and the choices in front of you.
Start here →TPLO vs TTA vs Lateral Suture, Compared
What each surgery does, which dogs it suits, cost ranges, complications, and what the systematic reviews actually support.
Compare the options →Cruciate Surgery Recovery, Week by Week
What eight weeks of confinement really involves, how to set the house up, and the signs that mean call the surgeon today.
Read the timeline →Managing a Torn CCL Without Surgery
What the evidence shows, which dogs conservative management suits, what a serious program involves, and when it's the wrong call.
Read the guide →Research Library
Every study behind these pages, in one place. Where the paper is open access and its license allows redistribution, we host the PDF so you can download it directly. For copyrighted and paywalled work, we link to the publisher so you can read it at the source. When in doubt about a license, we link out rather than host.
Canine parvovirus (CPV): vaccines, reviews, and antivirals
Sabyrzhan et al. (2025). Co-infection of canine parvovirus and canine circovirus in dogs with gastroenteritis (Kazakhstan). Frontiers in Cellular and Infection Microbiology 15:1645697.
Pearce, Spibey, Sutton & Tarpey (2023). Development of a novel canine parvovirus vaccine capable of stimulating protective immunity in four-week-old puppies in the face of high maternal antibodies (Nobivac DP PLUS). Vaccines 11(9):1499.
Zhou et al. (2025). Overview of recent advances in canine parvovirus research: current status and future perspectives. Microorganisms 13(1):47.
Su et al. (2024). Transcriptional differential analysis of the nitazoxanide-mediated anti-canine-parvovirus effect in F81 cells. Viruses 16(2):282.
Zhou et al. (2019). Inhibitory effects of antiviral drug candidates on canine parvovirus in F81 cells (nitazoxanide identified from a screen). Viruses 11(8):742.
Canine distemper (CDV): antivirals and treatment
Oliver-Guimerá, Murphy & Keel (2025). The nucleoside analog GS-441524 effectively attenuates in vitro replication of multiple lineages of circulating canine distemper viruses. Viruses 17(2):150.
Candela & Ortega (2025). Canine Distemper Virus: Special Issue Editorial. Viruses 17(12):1630.
Gastelum-Leyva et al. (2022). Silver nanoparticles in non-neurological and neurological canine distemper: a randomized clinical trial (n=207). Viruses 14(11):2329.
Xue et al. (2019). Antiviral efficacy of favipiravir (T-705) against canine distemper virus infection in vitro. BMC Veterinary Research 15:316.
Camero et al. (2022). ERDRP-0519 inhibits feline coronavirus in vitro (morbillivirus-family polymerase inhibitor). BMC Veterinary Research 18:55.
de Carvalho et al. (2017). 6-methylmercaptopurine riboside, a thiopurine nucleoside with antiviral activity against canine distemper virus in vitro. Virology Journal 14:141.
Giuliani et al. (2018). In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates. Drug Delivery 25(1):376-387.
Sarchahi, Arbabi & Mohebalian (2025). Effects of phenobarbital and prednisolone on the neurological signs of canine distemper. Veterinary Medicine and Science 11(5):e70479.
Canine distemper (CDV): neuropathology and neurological sequelae
Rendón-Marín et al. (2019). Tropism and molecular pathogenesis of canine distemper virus (review). Virology Journal 16:30.
Ulrich et al. (2014). Transcriptional changes in the brain favor a biphasic pattern of demyelination in canine distemper. PLOS ONE 9(4):e95917.
Klemens et al. (2019). Neurotoxic potential of reactive astrocytes in canine distemper demyelinating leukoencephalitis. Scientific Reports 9:11689.
Attig et al. (2019). Reactive oxygen species are key mediators of demyelination in canine distemper leukoencephalitis but not in Theiler’s murine encephalomyelitis. International Journal of Molecular Sciences 20(13):3217.
Lempp et al. (2014). New aspects of the pathogenesis of canine distemper leukoencephalitis (review). Viruses 6(7):2571-2601.
Spitzbarth et al. (2016). Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain and Behavior 6(9):e00472.
Lowrie & Garosi (2017). Classification of involuntary movements in dogs: myoclonus and myotonia (relevant to distemper myoclonus). Journal of Veterinary Internal Medicine 31(5):1531-1538.
Pinheiro et al. (2019). Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as a model for multiple sclerosis. Heliyon 5(6):e01857.
de Carvalho et al. (2012). Immunopathogenic and neurological mechanisms of canine distemper virus (review). Advances in Virology 2012:163860.
Read at the publisher (copyrighted or paywalled)
ASPCA (2024). Canine distemper virus: treatment (clinical guideline).
Read at publisherCopyright ASPCA, aspcapro.orgKrumm et al. (2014). An orally available, small-molecule polymerase inhibitor (ERDRP-0519) protects against lethal morbillivirus infection in a large animal model. Science Translational Medicine 6(232):232ra52.
Read at publisherPaywalled, Science Translational MedicineVandevelde & Zurbriggen (2005). Demyelination in canine distemper virus infection: a review. Acta Neuropathologica 109(1):56-68.
Read at publisherPaywalled, SpringerYu et al. (2025). Tocilizumab binds to the canine IL-6 receptor and elicits an in-vitro inhibitory biological response. Frontiers in Veterinary Science.
Read at publisherFrontiers (DOI pending confirmation)Lim et al. (2024). Canine parvovirus monoclonal antibody (CPMA) challenge study: 0% versus 57% mortality (basis for the Trutect/TrueTect approval). JAVMA 262(4).
Read at publisherPaywalled, AVMAdos Santos, Joaquim & Cassu (2022). Acupuncture in the neurological sequelae of canine distemper. Journal of Acupuncture and Meridian Studies 15(4):238-247.
Read at publisherOpen access, CC BY-NC 4.0
This library covers the core studies cited across these pages. Many more open-access papers (from MDPI, Frontiers, PLOS, BMC, and PMC) are referenced in the full syntheses linked above. If you need a specific paper that isn't listed, the citations in each page carry the DOI so you can find it at the source.